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[目的]探讨泸州地区反复不良妊娠夫妇相关病因。[方法]对625例不良妊娠夫妇进行解剖学、内分泌功能、细胞遗传学、TORCH-IgM、血型及血清血型免疫抗体滴度等检测。[结果]625对夫妇中女性子宫解剖异常54例(8.64%),男性生殖系统及精液异常23例(3.68%);内分泌异常45例(7.2%);染色体异常率为46例(7.36%),其中以平衡易位最常见;感染因素流产组中女性TORCH-IgM总阳性率28.96%(181/625),流产组阳性率与健康孕妇组比较差异具有统计学意义(P﹤0.05);97对血型不合夫妇共流产239次,人均流产2.46次。[结论]解剖结构异常、染色体畸变、内分泌异常,TORCH感染、ABO、Rh血型不合等与反复不良妊娠密切相关。
[Objective] To explore the related causes of couples with adverse pregnancy in Luzhou area. [Methods] Anatomy, endocrine function, cytogenetics, TORCH-IgM, blood type and serum antibody titer of 625 adverse pregnancy couples were detected. [Results] Among 625 couples, 54 cases (8.64%) had abnormal uterine anatomy, 23 cases (3.68%) had male reproductive system and semen abnormality, 45 cases (7.2%) had endocrine abnormality, 46 cases (7.36%) had abnormal chromosomal abnormality, , Of which the most common is the balance of translocation. The total positive rate of TORCH-IgM in women with abortion was 28.96% (181/625). The positive rate of miscarriage was significantly higher than that of healthy pregnant women (P <0.05). 97 239 pairs of miscarriage of blood type couple, 2.46 times the average abortion. [Conclusion] Anatomic structure abnormalities, chromosomal aberrations, endocrine abnormalities, TORCH infection, ABO, Rh blood group incompatibility are closely related to repeated adverse pregnancy.