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慢性病毒性肝炎(简称慢肝)的治疗尚无特效药物,宜注意合理的营养和休息,避免使用对肝脏有损害的物质,按病情和病程不同选用药物,现介绍慢肝治疗的近况如下。一、抗病毒治疗(一) 抗病毒药:阿糖腺苷(Ara-A)对DNA和RNA病毒均有抑制作用,应用于治疗慢性活动性肝炎(简称慢活肝)可见部分病例疾病的活动性程度及病毒标记的滴度均有持续性改善。三氮唑核苷(商品名Virazole)亦有报道治疗慢肝,近年我科使用亦认为有一定疗效。但上二药治疗例数尚少,需进一步研究。(二) 干扰素与干扰素诱生剂:干扰素(Interferon)亦是广谱抗病毒药。用人白细胞或成纤维细胞制备的干扰素治疗HBsAg阳性的慢活肝患者,均有使Dane颗粒标记(如HBeAg及DNA多聚酶)持久阴转的报告。但另有作者指出这些报道尚不能排除Dane颗粒自然消失的可能性。亦有提出合并使用干扰
The treatment of chronic viral hepatitis (referred to as slow liver) is no specific drugs, should pay attention to reasonable nutrition and rest, to avoid the use of substances that damage the liver, according to the disease and duration of the different selection of drugs, are introduced the status of chronic liver disease are as follows. First, antiviral therapy (A) Antiviral drugs: Ara-A on DNA and RNA viruses are inhibited, used in the treatment of chronic active hepatitis (referred to as slow living liver) can be seen in some cases of disease activity Sexuality and viral titer titers have continued to improve. Ribavirin (brand name Virazole) has also been reported for the treatment of chronic liver, in recent years, our department also considered that there is a certain effect. However, the number of cases on the two drugs is still small, need further study. (B) Interferon and interferon inducer: Interferon (Interferon) is also a broad-spectrum antiviral drug. Interferon prepared with human leukocytes or fibroblasts has been reported to permanently dull Dane particle markers (such as HBeAg and DNA polymerase) in HBsAg-positive patients with chronic liver disease. However, another author pointed out that these reports still can not rule out the possibility of natural disappearance of Dane particles. There are also proposed to use the interference