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神经病理性疼痛是由于外周或中枢神经损伤导致的慢性痛状态。慢性痛由痛觉传导通路功能的改变引起,包括外周感受器、脊髓到脊髓上和皮层(初级躯体感觉皮层SI和前扣带回ACC等)。SI是编码痛感觉成分(包括痛觉的程度和位置)的重要脑区。SI包括兴奋性锥体神经元和抑制性中间神经元。抑制性中间神经元包括:小清蛋白(parvalbumin,PV)阳性、生长抑素(somatostatin,SOM)阳性、血管活性肠肽(vasoactive intestinal polypeptide,VIP)阳性的中间神经元。在三种抑
Neuropathic pain is a chronic pain condition that results from injury to the periphery or central nervous system. Chronic pain is caused by alterations in the function of the pain pathways, including the peripheral sensory receptors, the spinal cord to the spinal cord and the cortex (primary somatosensory cortex SI and anterior cingulate ACC). SI is an important brain area that encodes pain sensation components, including the degree and location of pain. SI includes excitatory pyramidal neurons and inhibitory interneurons. Inhibitory interneurons include: parvalbumin (PV) positive, somatostatin (SOM) positive, vasoactive intestinal polypeptide (VIP) positive intermediate neurons. In three ways