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目的：观察辛伐他汀治疗颈动脉粥样硬化斑块的临床治疗效果。方法将颈动脉粥样硬化斑块的患者随机分为两组，其中治疗组110例，对照组110例，治疗组予辛伐他汀10mg 每晚顿服，对照组行其他非辛伐他汀药物治疗，观察时间为12个月，观察治疗前后颈动脉内膜中层厚度（IMT）、斑块面积、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL －C）和高密度脂蛋白胆固醇（HDL －C）的变化。结果治疗组治疗后颈动脉内膜一中层厚度（IMT）、斑块面积变小，总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL －C）水平显著下降，高密度脂蛋白胆固醇（HDL －C）水平显著升高，与治疗前比较．差异有统计学意义（P ＜0．05）。结论辛伐他汀不仅可以降低胆固醇，调节血脂，而且可以稳定斑块，甚至减轻动脉粥样硬化，对于预防心脑血管疾病起到了非常重要的作用。“,”Objective To observe the clinical therapeutic ef ect of simvastatin in the treatment of carotid atherosclerotic plaque.Methods 220 cases were examined by color Doppler ultra-sound findings of carotid atherosclerotic plaques were randomly divided into two groups,including 110 cases of treatment group,110 cases in the control group,the treatment group treated with simvastatin 10mg QN Po,the control of othernon simvastatin treatment group,the observation time was 12 months.The carotid artery intima were observed before and after treatment middle thickness,plaque area (IMT),triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL -C)and high density lipoprotein cholesterol (HDL -C)changes.Results the treatment group after the treatment of carotid intima media thickness (IMT),plaque area decreased,total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL -C)level was significantly decreased and high density lipoprotein cholesterol (HDL -C)levels were significantly increased,compared with those before treatment.The dif erence was statistical y significant (P <0.05).Conclusion simvastatin can reduce cholesterol,regulate blood lipid,but also can stabilize the plaque,and even reduce atherosclerosis,to a very important role in the pre-vention of cardiovascular and cerebrovascular diseases.