论文部分内容阅读
目的研究隐匿性肾小球肾炎患者血清胱抑素C水平的变化,评估血清CysC测定在隐匿性肾小球肾炎诊断中的意义。方法选取80例研究对象,其中观察组为隐匿性肾炎患者40例,对照组为健康成人40例,采用免疫透射比浊法分析受试者血清CysC和尿微量白蛋白水平。结果观察组和对照组之间在CysC和尿UmAl水平差异具有统计学意义(P<0.05);变量相关分析显示,CysC与UmAlb具有相关性,相关系数为0.69。诊断效果评价表明,CysC、UmAlb在ROC曲线下的面积分别为0.99、0.81。结论血清CysC可以作为隐匿性肾小球肾炎患者诊断和评估预后的理想生化指标,其诊断和监测预后效果优于尿UmAlb。
Objective To study the changes of serum cystatin C in patients with occult glomerulonephritis and evaluate the significance of serum CysC in the diagnosis of occult glomerulonephritis. Methods Totally 80 subjects were enrolled in this study. The observation group consisted of 40 patients with occult nephritis and the control group with 40 healthy adults. The levels of serum CysC and urinary albumin were measured by immunoturbidimetry. Results The differences of CysC and urinary UmAl between the observation group and the control group were statistically significant (P <0.05). Correlation analysis showed that there was a correlation between CysC and UmAlb with a correlation coefficient of 0.69. The diagnostic evaluation showed that the areas under the ROC curve of CysC and UmAlb were 0.99 and 0.81, respectively. Conclusion Serum CysC can be used as an ideal biochemical indicator in the diagnosis and assessment of prognosis in patients with occult glomerulonephritis, and its prognosis and prognosis are better than that of urine UmAlb.