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目的评价抗结核固定剂量复合剂(FDC)治疗新涂阳肺结核患者在贵州省结核病防治规划中的可行性。方法在贵州省6个县采用固定剂量复合剂和抗结核板式组合药分别对189例新涂阳肺结核患者进行治疗,比较其2月末痰涂片阴转率、治愈率及不良反应发生率。结果研究组和对照组患者2月末痰涂片阴转率、治愈率及不良反应发生率差异无统计学意义(P>0.05)。结论采用固定剂量复合剂对新涂阳肺结核患者进行治疗能取得与板式药相当的治疗疗效,在结核病防治规划中值得进一步推广。
Objective To evaluate the feasibility of anti-tuberculosis fixed-dose combination (FDC) in the treatment of tuberculosis patients in Guizhou Province. Methods A total of 189 patients with newly smear-positive pulmonary tuberculosis were treated with fixed-dose combination and anti-TB plate combination in 6 counties of Guizhou Province. The sputum smear negative conversion rate, cure rate and adverse reaction rate at the end of February were compared. Results There was no significant difference in the rate of negative conversion, cure rate and incidence of adverse reactions in the study group and the control group at the end of February (P> 0.05). Conclusions The treatment of patients with newly smear-positive pulmonary tuberculosis with fixed-dose combination can achieve the therapeutic effect equivalent to that of plate-type medicine and worth further promotion in the prevention and control of tuberculosis.