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目的:研究局部亚低温对急性脑出血患者血清炎症因子的影响。方法:将70例急性脑出血患者随机分为两组,常规治疗组(35例)予药物综合治疗,局部亚低温组(35例)在药物综合治疗基础上加用局部亚低温治疗,观察血清炎症因子[肿瘤坏死因子α(tumornecrosisfactorsα,TNFα)、白介素6(interleukin6,IL6)、C反应蛋白(C reactiveprotein,CRP)]的变化。结果:发病第3、7日时,局部亚低温组血清炎症因子[分别为:TNFα(7.6±4.2)μg/L,(3.5±2.4)μg/L;IL6(18.0±3.1)pmol/L,(6.8±2.3)pmol/L;CRP(18.3±4.0)mg/L,(5.0±1.6)mg/L]明显低于常规治疗组(分别为TNFα(12.4±7.3)μg/L,(6.6±3.2)μg/L;IL6(24.6±4.1)pmol/L,(9.5±2.5)pmol/L;CRP(27.1±7.3)mg/L,(14.2±3.6)mg/L),各数值比较差异均有统计学意义,均为P<0.01。结论:局部亚低温可有效降低脑出血后的炎症因子,减少炎症反应,发挥保护脑细胞作用。
Objective: To investigate the effect of local mild hypothermia on serum inflammatory factors in patients with acute cerebral hemorrhage. Methods: Seventy patients with acute intracerebral hemorrhage were randomly divided into two groups. The conventional treatment group (35 cases) was given drug combination therapy. The local mild hypothermia group (35 cases) was treated with local mild hypothermia on the basis of comprehensive drug therapy. Serum The changes of inflammatory cytokines (TNFα, IL6, C reactive protein (CRP)] were studied. Results: Serum inflammatory cytokines in the local mild hypothermia group at the 3rd and 7th days of onset were respectively: (7.6 ± 4.2) μg / L TNFα, (3.5 ± 2.4) μg / L and 18.0 ± 3.1 pmol / L, (6.8 ± 2.3) pmol / L; CRP (18.3 ± 4.0) mg / L, (5.0 ± 1.6) mg / L] were significantly lower than those in the conventional treatment group 3.2) μg / L, IL6 (24.6 ± 4.1) pmol / L, (9.5 ± 2.5) pmol / L and CRP (27.1 ± 7.3) mg / L, (14.2 ± 3.6) mg / L respectively) Statistically significant, all P <0.01. Conclusion: Local mild hypothermia can effectively reduce the inflammatory factors after intracerebral hemorrhage, reduce the inflammatory reaction, and play a role in protecting brain cells.