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【目的】探讨在血糖控制良好的妊娠糖尿病(GDM)孕妇中,脐血瘦素与新生儿体质指标的关系。【方法】收集2006年11月至2007年2月于我科住院分娩的孕妇150例,其中糖代谢异常,包括GDM和妊娠期糖耐量异常(GIGT),而且血糖控制良好的孕妇73例,糖耐量正常的孕妇77例,其新生儿分为大于胎龄儿(LGA)25例和适于胎龄儿(AGA)125例两组。比较分析了两组新生儿的体质指标、脐血瘦素等指标。【结果】LGA与AGA相比,脐血的瘦素水平LGA组的更高(16.17±12.53vs10.84±8.41μg/L,P<0.05)。在糖代谢异常孕妇的新生儿中,LGA新生儿的出生体质量与脐血的瘦素水平正相关(r=0.974,P<0.05);在糖耐量正常孕妇的新生儿中,LGA新生儿的体质指标与脐血瘦素不相关。【结论】脐血瘦素与新生儿体质量密切相关;脐血瘦素可能参与了糖代谢异常孕妇分娩LGA的发病机制。
【Objective】 To investigate the relationship between cord blood leptin and newborn physical fitness in pregnant women with gestational diabetes mellitus (GDM) with good glycemic control. 【Methods】 150 pregnant women who were hospitalized in our department from November 2006 to February 2007 were collected. Among them, there were abnormal glucose metabolism, including GDM and GIGT, and 73 pregnant women with good glycemic control, Totally 77 pregnant women with normal tolerance were divided into two groups: 25 cases of LGA and 125 cases of AGA. Comparative analysis of the two groups of newborns physical indicators, cord blood leptin and other indicators. 【Results】 Compared with AGA, the leptin level of cord blood in LGA group was higher than LGA group (16.17 ± 12.53vs10.84 ± 8.41μg / L, P <0.05). In newborn infants with abnormal glucose metabolism, the birth weight of LGA newborns was positively correlated with the leptin level of cord blood (r = 0.974, P <0.05). Among neonates with normal glucose tolerance, LGA neonates Physical indicators and cord blood leptin is not related. 【Conclusion】 Cord blood leptin is closely related to the body weight of newborns; cord blood leptin may be involved in the pathogenesis of LGA in pregnant women with abnormal glucose metabolism.