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Two new sesquiterpene lactone glycosides were isolated from the whole plant of Sonchus transcaspicus. Their structures were elucidated as 1β-O-β-D-glucopyranosy-5α, 6βH-eudesma-3-en-12, 6α-olide and 1β-O-β-D-glucopyranosy-15-O-(p-hydroxylphenylacetate)-5α