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目的探讨彩色多普勒超声及P63蛋白在完全性葡萄胎(CM)、部分性葡萄胎(PM)及水肿流产绒毛(HA)诊断中的作用。方法应用免疫组化的方法检测P63蛋白在完全性葡萄胎62例,部分性葡萄胎60例,水肿绒毛60例组织中的表达,并应用彩色多普勒超声对HA,PM,CM进行图像分析比较。结果 P63在62例HA中有55例(88.7%)呈阳性表达,60例PM中有50例(83.3%)呈阳性表达,60例CM中有6例(10%)呈阳性表达,并且在CM中的阳性强度较弱。3种病变P63染色阳性率统计分析显示:CM与PM及HA之间均存在显著性差异(P<0.01),而PM与HA之间无显著性差异(P>0.05)。结论 P63免疫组化是诊断CM的一种高敏感性、高特异性方法,同时用彩超CM,对早期CM的发现有重大作用。
Objective To explore the role of color Doppler ultrasound and P63 protein in the diagnosis of complete moles (CM), partial moles (PM) and edema and abortion (HA). Methods Immunohistochemical method was used to detect the expression of P63 protein in 62 cases of complete hydatidiform mole, 60 cases of partial hydatidiform mole and 60 cases of edema. The images of HA, PM and CM were analyzed by color Doppler ultrasonography Compare Results P63 was positive in 55 cases (88.7%) of 62 cases of HA, 50 cases (83.3%) in 60 cases of PM, 6 cases (10%) of 60 cases of CM were positive, The positive intensity in CM is weaker. Statistical analysis of the positive rate of P63 staining showed that there was a significant difference between CM and PM and HA (P <0.01), but no significant difference between PM and HA (P> 0.05). Conclusions P63 immunohistochemistry is a highly sensitive and specific method for the diagnosis of CM. At the same time, color Doppler ultrasonography can play an important role in the early detection of CM.