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目的研究鸡蛋(含蛋壳)对大鼠胃溃疡的影响,机制及其与西药药效的比较。方法以无水乙醇灌胃复制胃溃疡模型,从胃液的pH,胃粘膜溃疡指数和损伤程度三方面观察鸡蛋(含蛋壳)A组,西药B组:西咪替丁+东莨菪碱,空白C组(生理盐水)治疗大鼠消化性溃疡的情况。探讨鸡蛋(含蛋壳)的治疗作用和机制。结果以2ml蛋花汤和0.032g蛋壳粉灌胃4d,2次/d,可明显防止大鼠消化性溃疡的发生,与空白组(pH=2.8333)比较,鸡蛋(含蛋壳)组(pH=6.5833)能降低胃液的酸度(P<0.05);西药组(pH=6.8333)与鸡蛋(含蛋壳)组(pH=6.5833)之间的比较(P<0.05);与空白组(溃疡指数=114.00)比较,鸡蛋(含蛋壳)组(溃疡指数=56.67)能减轻胃粘膜的溃疡程度(P<0.05);粘膜损伤程度:C组>A组>B组。结论蛋花汤中含有的脂肪,蛋白等,尤其卵磷脂可以保护胃粘膜免受胃液中H+的损伤,及其中的还原性成分可以防止胃粘膜受氧自由基的损害,蛋壳含CaCO3可以中和胃液中的H+,对胃粘膜起到保护作用。
Objective To study the effect of egg (including egg shell) on gastric ulcer in rats and its mechanism and comparison with western medicine. Methods The model of gastric ulcer was established by intragastric administration of ethanol. The egg (including egg shell) group A was observed from gastric juice pH, gastric mucosal ulcer index and degree of injury. Group B: cimetidine + scopolamine and blank group C (Saline) for the treatment of peptic ulcer in rats. To explore the therapeutic effect and mechanism of egg (including egg shell). Results 2ml egg flower soup and 0.032g eggshell powder were administered orally for 4 days for 2 times per day, which could obviously prevent the occurrence of peptic ulcer in rats. Compared with the blank group (pH = 2.8333) (P <0.05). Compared with the control group (pH = 6.5833), the acidity of gastric juice decreased (P <0.05) Index = 114.00), the egg (including egg shell) group (ulcer index = 56.67) can reduce the degree of gastric mucosal ulcer (P <0.05); mucosal injury: C group> A group> B group. Conclusion Egg flower soup contains fat, protein, etc., especially lecithin can protect the gastric mucosa from gastric juice H + damage, and the reducing component of which can prevent gastric mucosal damage by oxygen free radicals, eggshell containing CaCO3 can be And gastric juice in the H, gastric mucosa play a protective effect.