最近,甲醛灭活的全病毒甲型肝炎疫苗(第一种获准使用的甲型肝炎疫苗)已在许多国家得到应用,减毒活疫苗也在中国获准使用.其他可能的疫苗研制途径包括应用传统或重组DNA技术获得亚单位疫苗、空核壳疫苗、活病毒或细菌载体疫苗、基因免疫接种和抗独特型抗体疫苗,本文对这些研制途径作一概述. Formaldehyde-inactivated whole-virus hepatitis A vaccine (the first approved hepatitis A vaccine) has recently been applied in many countries and live-attenuated vaccines are also approved in China.Other possible approaches to vaccine development include the use of traditional Or recombinant DNA technology to obtain subunit vaccine, empty core-shell vaccine, live virus or bacterial vector vaccine, gene vaccination and anti-idiotypic antibody vaccine, the paper gives an overview of these research methods.