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通过蹬车运动试验，观察３６例常规尿蛋白检查阴性的糖尿病患者，运动前、后血、尿中β２微球蛋白（β２－ＭＧ）改变，结果１７例Ⅰ型糖尿病患者蹬车后３０分钟和６０分钟尿β２－ＭＧ较蹬车前明显增加，１９例亚型糖尿病患者蹬车运动后６０分钟尿β２－ＭＧ增加，而对照组无一改变。对２８例运动后尿β２－ＭＧ增加者，随诊５年后２２例（７８．６％）尿蛋白转为阳性，说明ＤＭ患者运动后β２－ＭＧ改变可能有助于糖尿病肾病的早期发现。
By treadmill exercise test, 36 patients with negative urine protein were observed before and after exercise, blood, urinary β2-microglobulin (β2-MG) changes in the results of 17 cases of type 1 diabetes mellitus 30 minutes after pedaling and Urinary β2-MG at 60 minutes increased significantly compared with that before treadmill exercise, urinary β2-MG increased at 60 minutes after treadmill exercise in 19 patients with type 2 diabetes, and none in the control group. Of the 28 patients with urinary β2-MG increased after urination, 22 cases (78.6%) urinary protein turned positive after 5 years of follow-up, indicating that the changes of β2-MG after exercise may contribute to the early detection of diabetic nephropathy.