Adalimumab-induced interstitial pneumonia in a patient with Crohn's disease

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:milin1215
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
There are several reports of anti-tumor necrosis factor(TNF)-induced lung disease,especially in patients with rheumatologic diseases.Adalimumab is an antiTNF drug used to induce and maintain remission in patients with immune-mediated diseases,such as Crohn’s disease.Although pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease,biologic therapy could also be a cause of lung injury.Only few cases of adalimumab-induced lung toxicity have been reported,and the majority of them were in patients with rheumatologic diseases.Lung injury secondary to anti-TNF therapy should,after ruling out other etiologies,be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs.A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis. There are several reports of anti-tumor necrosis factor (TNF) -induced lung disease, especially in patients with rheumatologic diseases. Adalimumab is an anti-TNF drug used to induce and maintain remission in patients with immune-mediated diseases, such as Crohn’s disease. Although pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease, biologic therapy could also be a cause of lung injury. Of the few cases of adalimumab-induced lung toxicity have been reported, and the majority of them were in patients with rheumatologic diseases. Lung injury secondary to anti-TNF therapy should, after ruling out other etiologies, be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs. A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis.
其他文献
采用网络调查法与文献计量法,以国家社科基金项目数据库以及中国知网为数据源,对知识管理的立项情况和论文发表情况进行统计,并从年度分布、项目类型、学科分布、项目负责人
Endoscopic retrograde cholangiopancreatography(ERCP) is an endoscopic procedure with high frequency of accidental symptoms, and particularly some patients who d
领导干部的形象对人们是一种非权力性影响力。它关系到党的路线、方针、政策能否贯彻执行,关系到党风政风的好坏,关系到在人民群众中的权威和威信,它在从政行为中占据非常重
目的评估高病毒载量的HBeAg阳性慢性乙型肝炎(CHB)的抗病毒治疗效果。方法采用前瞻性、多中心、非随机、开放的研究方法,将120例高病毒载量的HBeAg阳性的入选病例均分为三组,
目的了解宝鸡地区2005年以后肾综合征出血热病监测情况及流行变化规律,为本地区出血热的防制提供科学依据。方法对宝鸡地区2005-2012年肾综合征出血热病人的急性期血清标本进
目的掌握黎平县2008-2012年病毒性肝炎流行特征及规律,为制定病毒性肝炎防控措施提供科学依据。方法采用描述性流行病学方法对黎平县2008-2012年病毒性肝炎疫情资料进行统计
延安市旅游产业蓬勃发展,旅游综合收入稳步增长。以红色旅游为核心,以黄河文化、黄土风情文化、黄帝文化为主导方向,延安市旅游产业正积极拓展旅游发展方向、开发旅游品牌文
AIM: To investigate clinical and biochemical features of hepatorenal syndrome(HRS), to assess short and long- term survival evaluating potential predictors of e
浙江省绍兴县大香林乡村休闲旅游区地处我国著名的会稽山余脉和鉴湖之畔,介于杭州与绍兴之间,距绍兴县城柯桥仅6公里,是绍兴县进一步做大做强旅游产业、打造“南闲”大旅游板
树立“以人为本”的思想,正确处理工作中的几个问题。1.善于授权,满足中层领导“自我实现”、“受人尊重”的需要。要学会善于授权,可以使自己从繁杂的事务工作中解脱出来,集中精