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为了解丙肝病毒（ＨＣＶ）感染与我国肝细胞癌（ＨＣＣ）之间的关系，以及ＨＣＶ抗原成分（ＨＣＡｇ的）在ＨＣＣ组织中的分布状况，应用鼠抗ＨＣＶ单克隆抗体，采用免疫组化技术检测ＨＣＣ组织中ＨＣＡｇ的表达，同时检测了乙肝病毒表面抗原（ＨＢｓＡｇ）。结果：４０例ＨＣＣ标本组织中ＨＣＡｇ、ＨＢｓＡｇ检出率分别为１７．５％（７／４０）和７０％（２８／４０），其中单一ＨＣＡｇ阳性者仅１例，ＨＣＡｇ和ＨＢｓＡｇ同时存在的检出率为１５％（６／４０）。镜下见ＨＣＡｇ呈细颗粒状分布于细胞胞浆，ＨＣＡｇ阳性细胞以局灶型分布为主。提示我国部分肝癌患者的癌组织中确实存在ＨＣＶ，ＨＣＶ感染可能是除乙肝病毒以外，导致我国ＨＣＣ发生的另一相关因素。
To understand the relationship between Hepatitis C virus (HCV) infection and China’s hepatocellular carcinoma (HCC), and the distribution of HCV antigens (HCAg) in HCC tissues, mouse anti-HCV monoclonal antibodies were used to perform immunohistochemistry. The expression of HCAg in HCC tissues was detected and the hepatitis B virus surface antigen (HBsAg) was detected. Results: The detection rates of HCAg and HBsAg in 40 specimens of HCC specimens were 17.5% (7/40) and 70% (28/40), respectively, of which only 1 specimen was positive for HCAg, and HCAg and HBsAg were detected at the same time. The rate is 15% (6/40). Under the microscope, HCAg was distributed in cytoplasm in fine particles, and HCAg positive cells were mainly localized. It is suggested that HCV does exist in the cancer tissues of some patients with liver cancer in China. HCV infection may be another factor that causes HCC in China in addition to hepatitis B virus.