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目的了解FG20210A基因变异与中国人脑动脉血栓形成的关系,该基因变异是否脑动脉血栓形成的危险因素及其在中国汉族人种的分布频率。方法49例首发脑动脉血栓形成40～78岁患者及46例健康对照组作为研究对象,进行FG20210A突变分析。结果患者及健康对照组均为FG20210G纯合子。结论中国汉族人脑动脉血栓形成患者中不存在FG20210A变异,FG20210A突变不足以构成脑动脉血栓性疾病的独立危险因素及发病原因。
Objective To investigate the relationship between FG20210A gene mutation and cerebral arterial thrombosis in China, whether the gene mutation is the risk factor of cerebral arterial thrombosis and its distribution frequency in Chinese Han population. Methods Forty-nine patients with first-episode cerebral thrombosis aged 40-78 years and 46 healthy controls were enrolled in this study. Mutation analysis of FG20210A was performed. Results Both patients and healthy controls were homozygous FG20210G. Conclusion There is no FG20210A mutation in patients with cerebral arterial thrombosis in Chinese Han nationality. The mutation of FG20210A is not enough to constitute an independent risk factor for cerebral arterial thrombosis and its causes.