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2型糖尿病是遗传因素和环境因素长期作用的结果 ,胰岛素抵抗和胰岛素分泌不足是目前公认的重要的发病机制。代谢因素诸如糖毒性、脂毒性参与胰岛素抵抗和胰岛 β细胞功能衰竭的病理过程 ,是促进 2型糖尿病发病的因素之一。脂毒性是指持续的高水平的游离脂肪酸 (FFA)所造成的 β
Type 2 diabetes is a long-term result of genetic and environmental factors, insulin resistance and insulin secretion is currently recognized as an important pathogenesis. Metabolic factors such as sugar toxicity, lipid toxicity involved in insulin resistance and pancreatic β-cell failure in the pathological process is one of the factors to promote the incidence of type 2 diabetes. Lipotoxicity refers to the beta that results from sustained high levels of free fatty acids (FFA)