全世界约有50%的人患有幽门螺杆菌(Hp)相关性胃肠疾病[1]。Hp感染与慢性胃炎、消化性溃疡、胃癌的关系日益受到重视[2]。研究发现,Hp的致病因子分两类:一类是定植因子,决定Hp在体内的定居;另一类是毒力因子,决定感染后是否导致炎症以及溃疡的发生。已知毒力因子有LPS、尿素酶、 Approximately 50% of people worldwide have H. pylori-associated gastrointestinal disorders [1]. The relationship between Hp infection and chronic gastritis, peptic ulcer, gastric cancer has received increasing attention [2]. The study found that Hp’s pathogenic factors fall into two categories: one is the colonization factor that determines Hp colonization in the body; the other is a virulence factor that determines whether the infection leads to inflammation and ulceration. Known virulence factors are LPS, urease,