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目的观察ＳＤ大鼠肝硬变门脉高压形成过程中ＴＮＦ浓度与肝损伤的关系．方法采用放射免疫测定法．团体ｔ检验．结果ＴＮＦ水平（ｎｇ／Ｌ）在早（１２２±０２６）中（１２１±０２３）晚（１２３±０１７）三期肝硬变中与正常组（０９７±０２３）相比明显升高（Ｐ＜００５）；与门脉压力变化无明显相关．结论ＴＮＦ水平升高，加重了肝脏损伤和肝纤维化病变，与门脉压力变化无关．
Objective To observe the relationship between TNF concentration and liver injury during the formation of portal hypertension in cirrhotic rats. Methods Radioimmunoassay was used. Group t test. Results TNF levels (ng / L) were significantly higher in patients with stage Ⅲ cirrhosis than in normal subjects (122 ± 026) (121 ± 023) and (023 ± 017) 97 ± 023) (P <005), but no significant correlation with changes of portal pressure. CONCLUSIONS: TNF levels are elevated, which aggravate the pathological changes of liver injury and hepatic fibrosis, and have no relation with changes of portal pressure.