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目的探讨心理干预对乳腺癌术后患者血清中肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)和白细胞介素8(IL-8)水平的影响。方法选取2014年1月至2015年1月间收治的98例乳腺癌手术患者,按照随机数字表法将患者分为研究组和对照组,每组49例。研究组患者在常规护理基础上给予心理干预,对照组患者仅给予常规护理。应用酶联免疫吸附法测量干预前后两组患者血清中TNF-α、hs-CRP和IL-8水平。结果干预前两组患者血清中TNF-α、hs-CRP和IL-8水平比较差异均无统计学意义(均P>0.05)。干预后,两组患者TNF-α、hs-CRP和IL-8水平均显著降低,与干预前比较差异均有统计学意义(均P<0.05);研究组患者TNF-α、hs-CRP和IL-8水平显著低于对照组,组间比较差异均有统计学意义(均P<0.05)。结论心理干预应用于术后乳腺癌患者具有较好的临床疗效,可有效地降低患者体内炎性因子水平。
Objective To investigate the effect of psychological intervention on serum levels of tumor necrosis factor α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and interleukin 8 (IL-8) in postoperative patients with breast cancer. Methods A total of 98 patients undergoing breast cancer surgery from January 2014 to January 2015 were selected and divided into study group and control group according to random number table method, with 49 cases in each group. Patients in the study group were given psychological intervention on the basis of routine nursing care while patients in the control group were given only routine nursing care. Serum levels of TNF-α, hs-CRP and IL-8 were measured by enzyme-linked immunosorbent assay before and after intervention. Results There was no significant difference in serum TNF-α, hs-CRP and IL-8 levels between the two groups before intervention (all P> 0.05). After intervention, the levels of TNF-α, hs-CRP and IL-8 in both groups were significantly lower than those before intervention (all P <0.05) IL-8 levels were significantly lower than the control group, the difference was statistically significant between the two groups (all P <0.05). Conclusion Psychological intervention in patients with postoperative breast cancer has a good clinical efficacy, which can effectively reduce the level of inflammatory cytokines in patients.