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[目的]观察重组人脑利钠肽（rh-BNP）治疗急性心肌梗死（AMI）并发心力衰竭的疗效。[方法]50例AMI合并心力衰竭患者随机分为两组，观察组25例在常规治疗的基础上加用rh-BNP，对照组给予常规治疗，观察治疗前后两组患者临床疗效、尿量、N末端B型利钠肽原（NT-proBNP）等指标变化及心功能改善情况。[结果]治疗后观察组的总有效率显著优于对照组，且两组相比较差异有显著性（84％vs68％，P＜0．01），观察组及对照组通过治疗后，临床观察指标均有明显好转，而观察组较对照组改善更为显著。[结论]与传统药物治疗相比，rh-BNP能明显改善AMI后心力衰竭患者的心功能，且不增加副作用。“,”[Objective]To observe the efficacy of recombinant brain natriuretic peptide (rh-BNP) for the treatment of patients with acute myocardial infarction (AMI) complicated by heart failure .[Methods]A total of 50 AMI patients complicated by heart failure were randomly divided into two groups .The observation group was additionally treated with rh-BNP based on the conventional therapy ,while the control group received the routine therapy .Clinical efficacy ,the change of urine volume and NT-proBNP and the improvement of cardiac function were observed before and after treatment .[Results]After treatment ,the total effective rate of obser-vation group was obviously better than that of control group ,and there was significantly difference between two groups( P < 0 .01) .After treatment ,clinical observation indicators in two groups were obviously im-proved ,but the improvement of observation group was more significant than that of control group .[Conclu-sion]Compared with traditional drug therapy ,rh-BNP can obviously improve cardiac function of patients with heart failure after AMI and not increase the side effect .