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本实验旨在通过压力波作用于大鼠，观察压力波能否引起肝脏的功能改变，为临床上高速投射物伤的诊治提供参考。结果发现：压力波致伤后，大鼠肺脏、肝脏表面有出血点片，可见肠穿孔及肝脏表面裂口等改变。血浆ＡＬＴ在０．５ｈ时显著升高，以后逐渐回落。血浆白蛋白含量、肝脏组织白蛋白ｍＲＮＡ水平于伤后逐渐减低，到伤后２４ｈ时明显低于对照组。腹腔巨噬细胞ＩＬ－１分泌能力于伤后０，５ｈ减弱，但以后逐渐恢复，到２４ｈ时明显高于对照值。本研究在没有失血、组织坏死等在体实验干扰因素的条件下，发现高速投射物压力波本身可致肝脏等器官损伤，使肝脏合成白蛋白的能力下降。肝脏损伤的机理与压力波的直接作用、空腔形成作用以及激活巨噬细胞释放的ＩＬ－１等因子有关。该实验提示压力波对机体组织器官有间接影响。
The purpose of this experiment is to observe the effect of pressure wave on the function of liver by pressure wave and to provide a reference for the diagnosis and treatment of high speed projection material injury. The results showed that: after pressure wave injury, there were bleeding spots on the surface of lung and liver in rats, which showed intestinal perforation and liver surface rupture. Plasma ALT significantly increased at 0.5h, then gradually decreased. Plasma albumin, liver tissue albumin mRNA levels gradually decreased after injury, to 24h after injury was significantly lower than the control group. IL-1 secreting capacity of peritoneal macrophages decreased at 0,5h after injury, but gradually recovered after 24 hours, which was significantly higher than that of control. In the absence of blood loss, tissue necrosis and other interference factors in vivo experiments, we found that high-speed projectile pressure wave itself can cause liver damage and other organs, so that the ability of the liver synthesis of albumin decreased. The mechanism of liver injury is related to the direct effect of pressure wave, cavity formation and activation of IL-1 released by macrophages. The experiment suggests that pressure waves have an indirect effect on tissues and organs of the body.