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目的观察室内醇酸色漆挥发物对小鼠多器官超氧化物歧化酶的抑制作用。方法将30只ICR小鼠分为3 h急性染毒组、30 h染毒组和对照组,每组10只;以醇酸色漆为受试物应用静式吸入染毒方法,染毒期间及恢复期观察其行为变化,染毒后测定其心脏、肺脏、肝脏、肾脏中超氧化物歧化酶(SOD)的水平。结果3 h急性染毒组,小鼠吸入醇酸色漆挥发物对心、肾组织SOD酶活力影响与对照组比较,差异无统计学意义(P>0.05);肺、肝组织SOD酶活力分别为(74.89±34.29)、(84.31±18.53) U/mg pro,与对照组比较明显降低,差异有统计学意义(P<0.01)。30 h染毒组,小鼠吸入醇酸色漆挥发物其心、肺、肝组织SOD酶活力(32.5±15.64)、(35.47±17.43)、(68.15±12.92)U/mg pro,与对照组比较明显下降,差异有统计学意义(P<0.01);肾组织SOD酶活力的变化不明显,与对照组比较,差异无统计学意义(P>0.05)。结论醇酸色漆挥发物可对小鼠多器官SOD产生抑制作用,具有一定的毒性作用。
Objective To observe the inhibitory effect of indoor alkyd varnish on multiple organ superoxide dismutase (SOD) in mice. Methods 30 ICR mice were divided into 3 hours acute exposure group, 30 hours exposure group and control group, with 10 rats in each group. Alkaline paints were used as the test substance to inhale by inhalation. And convalescence were observed behavioral changes, after exposure to the determination of the heart, lung, liver, kidney superoxide dismutase (SOD) levels. Results There was no significant difference in the activity of SOD between hearts and kidneys in 3 h acute exposure group and mice when compared with control group (P> 0.05). The activities of SOD in lung and liver tissue were (74.89 ± 34.29) and (84.31 ± 18.53) U / mg pro significantly decreased compared with the control group (P <0.01). The activity of SOD in the hearts, lungs and liver tissues of mice exposed to alkyd paints for 30 h was (32.5 ± 15.64), (35.47 ± 17.43), (68.15 ± 12.92) U / mg pro, respectively. Compared with the control group (P <0.01). There was no significant difference in the activity of SOD between renal tissues and the control group (P> 0.05). Conclusion Alkyd paints volatile compounds can inhibit the mouse multiple organ SOD, has a certain toxicity.