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为探讨激素性股骨头缺血坏死家兔血浆中一氧化氮 (NO)的变化及骨复生对其的影响 ,采用给日本大耳白兔大剂量肌肉注射醋酸波尼松龙 8W的方法 ,造成激素性股骨头缺血坏死的病理模型 ,随机分为骨复生组、马氏骨片组、模型对照组与空白对照组。结果显示模型组血浆 NO含量降低 ,与空白对照组相比差异非常显著 (P<0 .0 1)。治疗 4周后 ,骨复生组、马氏骨片组与模型组相比血浆 NO含量升高 (P<0 .0 5 )。两治疗组相比无明显差异 (P>0 .0 5 )。表明激素诱导的股骨头缺血坏死与血管功能障碍、血管内皮受损有关。骨复生具有升高血浆 NO浓度、保护血管内皮、改善微循环、改善血瘀状态、抑制血栓形成 ,而这些作用是其治疗激素性股骨头缺血坏死的可能机制之一
In order to investigate the changes of nitric oxide (NO) in plasma of rabbits with steroid-induced avascular necrosis of the femoral head and the effect of bone regeneration, a method of intramuscular injection of 8 mL of bonixone acetate into large ear rabbits in Japan was used. The pathological model of steroid-induced avascular necrosis of the femoral head was randomly divided into the bone regeneration group, the Ma’s bone fragment group, the model control group, and the blank control group. The results showed that the plasma NO levels in the model group decreased significantly compared with the control group (P < 0.01). After 4 weeks of treatment, the levels of plasma NO in the bone resuscitation group and the Markov bone group were higher than those in the model group (P<0.05). There was no significant difference between the two treatment groups (P>0.05). It shows that hormone-induced avascular necrosis of the femoral head is associated with vascular dysfunction and damage to the vascular endothelium. Bone resuscitation has the effects of increasing plasma NO concentration, protecting vascular endothelium, improving microcirculation, improving blood stasis, and inhibiting thrombosis, and these effects are one of possible mechanisms for the treatment of steroid-induced avascular necrosis of the femoral head.