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目的:研究表皮生长因子受体(epidermal growth factor receptor,EGFR)在口腔扁平苔藓(OLP)、口腔鳞状细胞乳头瘤(SCP)及口腔鳞状细胞癌(SCC)中的表达,探讨其在口腔黏膜炎症、增生及癌发生过程中的意义。方法:用免疫组化方法检测EGFR在20例口腔黏膜扁平苔藓(单纯增生10例,伴糜烂10例)、20例口腔乳头瘤、20例口腔鳞状细胞癌及5例正常口腔黏膜中的表达。采用Fromowitz法计数阳性细胞。应用SPSS11.5软件包分析EGFR在不同病变中的表达差异。结果:EGFR在非糜烂型扁平苔藓组主要表现为弱阳性表达;糜烂型扁平苔藓组强阳性表达率为20%;乳头瘤组的强阳性表达率为25%;鳞状细胞癌的强阳性表达率为60%。扁平苔藓糜烂组和非糜烂组之间EGFR强阳性表达率有显著差异(P<0.05);糜烂组OLP与乳头瘤组的强阳性表达率无显著差异;口腔鳞癌组的强阳性表达率显著高于扁平苔藓组及乳头瘤组。结论:EGFR可能成为口腔鳞癌化学预防作用的重要靶点。
Objective: To investigate the expression of epidermal growth factor receptor (EGFR) in oral lichen planus (OLP), oral squamous cell carcinoma (SCC) and oral squamous cell carcinoma (SCC) Mucosal inflammation, hyperplasia and the significance of carcinogenesis. Methods: The expression of EGFR was detected by immunohistochemistry in 20 cases of oral mucosa lichen planus (10 cases with simple hyperplasia, 10 cases with erosion), 20 cases of oral papilloma, 20 cases of oral squamous cell carcinoma and 5 cases of normal oral mucosa . Positive cells were counted by Fromowitz method. SPSS11.5 software package analysis of EGFR in different pathological differences in expression. Results: The expression of EGFR in non-erosive lichen planus was weakly positive, the positive rate was 20% in erosive lichen planus, the strong positive rate was 25% in papillary neoplasia, and strongly positive in squamous cell carcinoma The rate is 60%. There was a significant difference in the positive rate of EGFR between lichen erosive group and non-ablative group (P <0.05). There was no significant difference between OLP and papilloma group in erosive group. The strong positive rate of oral squamous cell carcinoma was significant Higher than that of lichen planus and papilloma group. Conclusion: EGFR may be an important target of chemoprevention in oral squamous cell carcinoma.