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报告2例浅表性膀胱肿瘤患者在经尿道直接灌注丝裂霉素C（MMC）作化疗过程中均出现了尿道狭窄，分别施行尿道狭窄处冷刀切开，加经尿道膀胱切除术（TURBT）和尿道内切开术加TURBT，均痊愈出院。并结合文献对其发病原因和机制、预防措施和处理方法进行了讨论，认为MMC反复直接接触并刺激尿道粘膜是导致尿道狭窄的直接原因。
Two patients with superficial bladder tumors were reported to have urethral stricture during transurethral direct perfusion of mitomycin C (MMC) for chemotherapy. They were treated with cold knife at the urethral stricture and transurethral cystectomy (TURBT). ) Intraurethral incision plus TURBT were cured and discharged. Combined with the literature, the etiology, mechanism, prevention measures and treatment methods were discussed. It is believed that repeated direct contact with MMC and stimulation of the urethral mucosa is the direct cause of urethral stricture.