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目的调查乌鲁木齐市肺结核患者对8种抗结核药物的耐药情况。方法将2011年5月1日-2012年9月30日间,乌鲁木齐市7区1县疾控中心结核病防治科收治的肺结核患者标本,用改良罗氏管进行分枝杆菌分离培养,培阳性菌株采用比例法对8种抗结核药物(异烟肼、利福平、乙胺丁醇、链霉素、氧氟沙星、卡那霉素、阿米卡星、卷曲霉素)进行药物敏感性试验,并对其耐药情况进行统计分析。结果 259例肺结核患者做药敏试验,其中耐药肺结核患者71例,总耐药率为27.41%,耐多药率为7.72%,广泛耐药率为3.09%。一线抗结核药物的耐药顺序为:异烟肼>链霉素>利福平>乙胺丁醇。原发性耐药与获得性耐药相比,耐多药患者经统计学分析差异有统计学意义(χ2=8.57,P=0.03)。结论对初治肺结核患者要实施有效的治疗管理,确保患者能规律治疗;对复治病人尽可能做药敏试验,依据药敏结果做个体化治疗。
Objective To investigate the drug resistance of 8 kinds of anti-tuberculosis drugs in patients with pulmonary tuberculosis in Urumqi. Methods From May 1, 2011 to September 30, 2012, samples of pulmonary tuberculosis patients admitted to tuberculosis prevention and treatment department of CDC 1 and CDC 7 districts in Urumqi were isolated and cultured with modified Roche tube for Mycobacterium. Proportional method Drug susceptibility testing of eight anti-TB drugs (isoniazid, rifampicin, ethambutol, streptomycin, ofloxacin, kanamycin, amikacin, capreomycin) , And statistical analysis of its resistance. Results A total of 259 pulmonary tuberculosis patients were tested for susceptibility. Among them, 71 cases were resistant to tuberculosis, with a total resistance rate of 27.41%, a resistance rate of 7.72%, and a broad-spectrum resistance rate of 3.09%. First-line anti-TB drug resistance sequence: isoniazid> streptomycin> rifampicin> ethambutol. Compared with acquired drug resistance, the multi-drug resistant patients had statistically significant difference (χ2 = 8.57, P = 0.03). Conclusions For patients with newly diagnosed pulmonary tuberculosis, effective treatment and management should be implemented to ensure regular treatment of patients. Drug susceptibility tests should be performed on patients receiving retreatment as soon as possible and individualized treatment should be based on drug susceptibility results.