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一个28岁的精神发育迟滞的男性患者。其父母体健且非亲缘关系,其母孕期6～8周患感冒而服用苯肾上腺素、复方扑尔敏等药物。以后又发生过一次脱水。患者出生时情况正常,但以后精神发育迟缓。20岁起,经常发脾气,同时出现了抑郁、缄默症状,情绪不稳定,运动缓慢、轻度痉挛性截瘫、精细运动障碍。26岁时染色体显带核型分析发现22号环状染色体。这时开始出现攻击行为。用甲硫哒嗪治疗,症状继续加重并出现静止性震颤、肌张力增高等症状。曾用大量镇静和抗精神病药物如:氟哌啶醇、苯巴比妥、氯丙嗪等,攻击行为加剧。试用利他灵20mg/日,18小时内患者的行为障碍戏剧性地改善。药物逐渐增至30mg/日时,症状完全控
A 28-year-old man with mental retardation. The parents of healthy and unrelated, the mother of 6 to 8 weeks of cold and taking phenylephrine, compound chlorpheniramine and other drugs. After another dehydration occurred. The patient was normal at birth, but later mentally retarded. 20 years old, often angry, at the same time there was depression, mute symptoms, emotional instability, slow motion, mild spastic paraplegia, fine motor disorder. At age 26, chromosome 22 karyotype analysis revealed a 22-loop chromosome. At this time began to attack. With thioridazine treatment, the symptoms continue to aggravate and appear rest tremor, muscle tension and other symptoms. Has used a lot of sedation and antipsychotic drugs such as: haloperidol, phenobarbital, chlorpromazine, aggressive behavior. Trial Ritalin 20mg / day, within 18 hours of patients with dramatic improvement in behavioral disorders. Gradually increase the drug to 30mg / day, the symptoms completely controlled