400例粪孵阳性的日本血吸虫病患者,按分层随机抽样分为四组,分别采用吡喹酮总剂量60、50、40与30mg/kg-日疗法进行治疗;治毕6个月粪孵阴转率依次为79.8％、71.7％、78.8％与70.1％,各剂量组的疗效无显著性差异。因此建议,可以总剂量40mg/kg治疗慢性血吸虫病,并对30mg/kg总剂量作进一步研究。 400 cases of stool-positive Japanese schistosomiasis patients were randomly divided into four groups according to stratified stratification, and were treated with praziquantel 60, 50, 40 and 30 mg / kg-day respectively. The negative conversion rates were 79.8%, 71.7%, 78.8% and 70.1%, respectively. There was no significant difference in the efficacy of each dose group. It is therefore recommended that chronic schistosomiasis be treated at a total dose of 40 mg / kg and further studies of the total dose of 30 mg / kg be conducted.