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男性免疫避孕的关键是寻找具有高度组织特异性、与生育功能密切相关的强抗原,1975年Shulman证实存在抗精子抗体,揭示了抗精子抗体与不育间的密切联系。我们曾对300例不育患者的血清抗体进行了相应精子膜抗原的分析,其中84 ku与72 ku蛋白的出现频率极高,约占不育抗体的40％。此外,在我们以往的工作中曾筛选到一株具有凝集作用的
The key to immune contraception in men is to find strong antigens that are highly tissue-specific and closely related to fertility. In 1975, Shulman confirmed the presence of anti-sperm antibodies and revealed the close relationship between anti-sperm antibodies and infertility. We have carried out the analysis of the corresponding sperm membrane antigens in 300 cases of infertile patients, in which 84 ku and 72 ku proteins appeared very frequently, accounting for about 40% of the infertile antibodies. In addition, we have screened for agglutination in our previous work