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目的:探讨新辅助化疗前后增殖细胞核抗原(PCNA)和抑癌基因p53在口腔鳞癌组织中的表达水平及其与化疗疗效的关系。方法:采用SP免疫组化法,对106例口腔鳞癌患者新辅助化疗前后的PCNA和p53表达水平进行检测,分析其表达水平与化疗疗效的关系。结果:①化疗前口腔鳞癌组织中PCNA高表达率为50.94%,显著高于化疗后23.58%(P<0.05);化疗前PCNA高表达患者化疗有效率为62.96%,显著高于PCNA低表达患者的有效率30.77%(P<0.05);②化疗前p53在口腔鳞癌中的阳性表达率为44.34%,显著高于化疗后21.60%(P<0.05);化疗前口腔鳞癌p53表达阴性患者的有效率为55.93%,显著高于p53表达阳性患者的有效率36.17%(P<0.05)。结论:新辅助化疗可明显降低PCNA和p53在口腔鳞癌组织中的表达水平,PCNA和p53的表达水平与新辅助化疗疗效具有显著的相关性,认为PCNA和p53的表达水平有可能成为口腔鳞癌化疗疗效的预测指标。
Objective: To investigate the expression of proliferating cell nuclear antigen (PCNA) and tumor suppressor gene p53 in oral squamous cell carcinoma before and after neoadjuvant chemotherapy and its relationship with the curative effect of chemotherapy. Methods: The expression of PCNA and p53 in 106 patients with oral squamous cell carcinoma before and after neoadjuvant chemotherapy were detected by SP immunohistochemistry. The relationship between the expression of PCNA and p53 was analyzed. Results: ① The high expression rate of PCNA in chemotherapy group was 50.94%, which was significantly higher than that in chemotherapy group (23.58%, P <0.05). The chemotherapy efficiency of PCNA before chemotherapy was 62.96%, which was significantly higher than that of PCNA The positive rate of p53 in oral squamous cell carcinoma was 44.34%, which was significantly higher than that of 21.60% after chemotherapy (P <0.05). The positive rate of p53 in oral squamous cell carcinoma before chemotherapy was negative The effective rate of patients was 55.93%, which was significantly higher than that of p53 positive patients (36.17%, P <0.05). Conclusions: Neoadjuvant chemotherapy can significantly reduce the expression of PCNA and p53 in oral squamous cell carcinoma, and the expression of PCNA and p53 is significantly correlated with the efficacy of neoadjuvant chemotherapy. It is suggested that the expressions of PCNA and p53 may be the target of oral squamous cell carcinoma Predictors of cancer chemotherapy efficacy.