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目的:探讨胃癌组织中CD44v6,增殖细胞核抗原(PCNA)的表达与胃癌侵袭性转移的关系以及预测胃癌淋巴结转移的价值。方法:应用免疫组织化学S－P法,对62例原发性胃癌中CD44v6,PCNA表达与胃癌淋巴结转移的关系进行检测。结果:胃癌组织中CD44v6阳性率为64．5%,PCNA阳性率为100%,其中弱阳性(Ⅰ~11级)表达率为24．2%,强阳性(Ⅲ~Ⅳ级)表达率为75．8%。随着肿瘤分化程度的降低,CD44v6,PCNA的表达增高;有淋巴结转移的病例中CD44v6的阳性率以及PCNA的强阳性表达率显著高于未发生淋巴结转移者。结论:胃癌组织中CD44v6,PCNA的异常表达,可能是胃癌发生、发展的一个重要分子学改变,联合检测其结果有助于评估胃癌的浸润、淋巴结转移和预后。
Objective: To investigate the relationship between the expression of CD44v6, proliferating cell nuclear antigen (PCNA) and the invasiveness and metastasis of gastric cancer in gastric cancer and to predict the value of lymph node metastasis in gastric cancer. Methods: The relationship between the expression of CD44v6 and PCNA in 62 cases of primary gastric cancer and lymph node metastasis of gastric cancer was detected by immunohistochemical S-P method. Results: The positive rate of CD44v6 in gastric cancer was 64.5% and the positive rate of PCNA was 100%. The expression rate of weak positive (grade Ⅰ ~ 11) was 24.2% and strong positive (grade Ⅲ ~ Ⅳ) was 75 .8%. With the decrease of tumor differentiation, the expression of CD44v6 and PCNA increased. The positive rate of CD44v6 and the strong positive rate of PCNA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis. Conclusion: Abnormal expression of CD44v6 and PCNA in gastric cancer may be an important molecular change in the occurrence and development of gastric cancer. The combined detection of these results is helpful to evaluate the infiltration, lymph node metastasis and prognosis of gastric cancer.