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应用分子生物学技术结合流行病学病例对照方法，对６０例脑梗塞病例进行了环境和遗传病因探讨。结果表明：我国不同地区人群ＸｂａⅠＸ~＋等位基因（突变型）频率差异明显，南方人群显著高于北方人群２～９倍，但与南北方的脑卒中死亡率不一致，说明 Ｘ~＋等位基因对脑卒中的保护作用较弱，可被高暴露的环境危险因素所修饰和掩盖；首次报道了我国农村人群 ＸｂａＩＸ~＋突变型等位基因的频率为 ０．０８３；与脑梗塞发病关系的分析发现：Ｘ－Ｘ~ ＋基因型者患脑梗塞的危险性较低（ＯＲ＝０．５６），但本研究尚未达到显著性水平；多因素Ｌｏｇｉｓｔｉｃ回归分析可见：Ｘ－Ｘ~＋基因型的保护性作用次于饮果酒和ＨＤＬ－Ｃ，但本研究尚未达显著性水平；将所有因素进入模型拟合时，显示脑梗塞重要的危险因素仍是舒张压、ＬＤＬ－Ｃ和Ｌｐ（ａ）等。
Using molecular biology techniques combined with epidemiological case-control methods, 60 cases of cerebral infarction were investigated for environmental and genetic causes. The results showed that the frequencies of XbaⅠX ~ + alleles (mutants) in different regions of China were significantly different from those in northern China, but significantly higher than those in northern China, but not consistent with the northern and southern stroke mortality rates, indicating that the X ~ + allele Genes have a weak protective effect on stroke and can be modified and masked by high environmental risk factors. The frequency of XbaIX ~ + mutant alleles in rural population in China was 0.083 for the first time. Analysis found that: X-X ~ + genotype had a lower risk of cerebral infarction (OR = 0.56), but this study has not yet reached a significant level; multivariate Logistic regression analysis shows: X-X ~ + genotype The protective effect was inferior to that of drinking wine and HDL-C, but this study has not yet reached the significance level. When all the factors were fitted into the model, the important risk factors of cerebral infarction were still diastolic blood pressure, LDL-C and Lp (a )Wait.