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支气管哮喘是多种细胞特别是嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞和气道上皮细胞及其细胞成分参与的气道慢性炎症性疾病,以气道炎症、可逆的气道阻塞和气道高反应性为其特征。信号转导子和转录激活子4(signal transducer and activator of transcription 4,STAT4)作为一种新型的能与靶基因调控区DNA结合的转录因子,介导白介素12的免疫反应与调节T细胞的分化,调节促炎因子与抗炎因子的应答,可能在支气管哮喘中发挥重要作用。该文从STAT4的基因位点、结构、信号转导途径及其与支气管哮喘的关系进行综述。
Bronchial asthma is a chronic airway inflammatory disease involving a variety of cells, especially eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells and their cellular components. Airway inflammation, reversible airway Blockage and airway hyperresponsiveness are hallmarks. Signal Transducer and Activator of transcription 4 (STAT4), as a novel transcription factor that binds to the DNA of the target gene regulatory region, mediates IL-12 immune response and regulates T cell differentiation , Regulating the response of pro-inflammatory and anti-inflammatory factors may play an important role in bronchial asthma. This review summarizes the gene location, structure, signal transduction pathway of STAT4 and its relationship with bronchial asthma.