采用MTT法观察28例腹腔内感染性炎性疾病所至多脏器功能不全综合征（MultipleOrganDysfunctionSyndrome，MODS）患者外周血单核细胞TNF、IL－1及IL－6分泌水平及通里攻下对其影响。结果表明，MODS患者外周血单核细胞分泌TNF、IL－1及IL－6的水平明显升高，与对照组比较TNF分泌水平升高最为显著（P＜0．01），IL-1及IL－6次之（P＜0．05），大承气汤治疗7日后，TNF、IL－1及IL－6分泌水平均下降，与对照组比较P＜0．05。观察结果表明采用通里攻下法治疗MDOS患者可抑制单核细胞分泌炎性细胞团子，抑制MODS发病时过度炎症反应从而起到脏器保护作用。 The levels of TNF, IL-1 and IL-6 in peripheral blood mononuclear cells were measured by MTT in 28 patients with multiple organ dysfunction syndrome (MODS) influences. The results showed that the levels of TNF, IL-1 and IL-6 secreted by peripheral blood mononuclear cells in MODS patients were significantly higher than those in control group (P <0.01). The levels of IL-1 and IL- (P <0.05). After 7 days of treatment, the levels of TNF, IL-1 and IL-6 secreted by Dachengqi Decoction decreased, P <0.05 compared with the control group. Observations show that the use of Tongliao attack treatment of patients with MDOS can inhibit the monocyte secretion of inflammatory cell lumps, inhibit MODS excessive inflammation in the pathogenesis to play organ protective effect.