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目的观察普萘洛尔联合尿素治疗婴儿眼部血管瘤的效果及安全性。方法眼部血管瘤患儿95例,依据治疗方法分为A组30例,B组30例,C组35例,A组局部注射尿素,B组口服普萘洛尔,C组联合应用尿素和普萘洛尔。观察3组不同分型血管瘤患者治疗效果,并进行比较。结果 A组治愈23例(76.7%),B组治愈19例(63.3%),C组治愈34例(97.1%),C组治愈率高于A,B组(P<0.05);C组表皮型、软组织肿块型、眶内混合型血管瘤治愈率均高于A,B组(P<0.05),A组表皮型、软组织肿块型血管瘤治愈率高于B组(P<0.05),眶内混合型血管瘤治愈率低于B组(P<0.05)。结论普萘洛尔联合尿素治疗表皮型、软组织肿块型、眶内混合型血管瘤均可获得良好效果,局部注射尿素适用于表皮型、软组织肿块型血管瘤,口服普萘洛尔适用于治疗眶内混合型血管瘤。
Objective To observe the efficacy and safety of propranolol combined with urea in the treatment of infantile ocular hemangiomas. Methods 95 cases of ocular hemangiomas were divided into group A (n = 30), group B (n = 30), group C (n = 35), group A with urea injection, group B with propranolol, group C with urea and Propranolol. Three groups of different types of hemangioma treatment were observed and compared. Results A group of 23 cases (76.7%) were cured, 19 cases (63.3%) were cured in group B, 34 cases (97.1%) were cured in group C. The cure rate in group C was higher than that in group A and B (P <0.05) (P <0.05). The cure rate of epidermal and soft tissue mass hemangioma in group A was higher than that in group B (P <0.05), and the orbital orbital The cure rate of internal hybrid hemangiomas was lower than that of group B (P <0.05). Conclusion Propranolol combined with urea treatment of epidermal, soft tissue mass, orbital mixed hemangioma can obtain good results, topical injection of urea for epidermal, soft tissue mass hemangioma, oral propranolol is suitable for the treatment of orbital Internal mixed hemangiomas.