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目前测定琥珀酰磺胺噻唑(succinylsulfathiazolum)的含量,一般采用水解后进行重氮化的方法。但具体步驟有所不同,例如1959年版药品規范和第15版美国药典规定在20%的氢氧化鈉溶液中,置水浴上加热水解两小时后,用M/10亚硝酸鈉溶液进行滴定,以碘化鉀淀粉指示液作为外指示剂指示終点;但1958年版英国药典則規定在稀盐酸中加热迴流水解30分钟,然后用M/10亚硝酸钠溶液滴定,以
At present, the content of succinylsulfathiazolum is generally measured by diazotization after hydrolysis. However, the specific steps are different. For example, the 1959 edition of Pharmacopoeia and the 15th edition of the U.S. Pharmacopoeia require titration with M / 10 sodium nitrite solution in a 20% sodium hydroxide solution for two hours by heating on a water bath and heating Potassium iodide starch indicator solution as an external indicator indicates the end point; but the 1958 edition of the British Pharmacopoeia is provided by heating in dilute hydrochloric acid reflux hydrolysis 30 minutes, then titration with M / 10 sodium nitrite solution to