作者在2年中用双盲、安慰剂对照法来检测哌吡二氮(pirenzepine)的季节性治疗对预防十二指肠溃疡复发的效果。哌吡二氮革是一种选择性的抗毒蕈碱药,据报道短程治疗对活动性十二指肠溃疡有效。作者曾发现在4及10月份十二指肠溃疡复发数明显增加。遂对81例内窥镜证实为愈合的十二指肠溃疡患者随机分为服哌吡二氮 The authors tested the effect of seasonal treatment with pirenzepine on the prevention of recurrence of duodenal ulcer in a 2-year, double-blind, placebo-controlled trial. Piperidine Dizarin is a selective anti-muscarinic drug, and it is reported that short-term treatment is effective for active duodenal ulcer. The authors have found significantly increased numbers of recurrences of duodenal ulcers in April and October. Then 81 cases of endoscopic confirmed healed duodenal ulcer patients were randomized to receive dipyridamole