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目的:观察氟桂利嗪、双丙戊酸钠及氟桂利嗪合用双丙戊酸钠对偏头痛发作的预防作用。方法:将124例偏头痛患者随机分为氟桂利嗪组(41例,A组)、双丙戊酸钠组(42例,B组)及氟桂利嗪合用双丙戊酸钠组(41例,C组),治疗2个月后对上述3组预防效果进行比较。结果:A组与B组总有效率分别为70.73%及73.81%,预防疗效差异无显著性(P<0.05),C组有效率92.68%,较A组、B组疗效好。结论:氟桂利嗪、双丙戊酸钠及氟桂利嗪合用双丙戊酸钠对偏头痛发作均有较好的预防作用,氟桂利嗪合用双丙戊酸钠较单独应用其中一种有更好的预防效果,但可能带来更多的不良反应。
Objective: To observe the preventive effect of flunarizine, divalproex and flunarizine in combination with divalproex on migraine attacks. Methods: A total of 124 patients with migraine were randomly divided into flunarizine group (41 cases, group A), sodium valproate group (42 cases, group B) and flunarizine combined with divalproex sodium group 41 cases, group C), after 2 months of treatment, the prevention effect of the above three groups were compared. Results: The total effective rates of group A and group B were 70.73% and 73.81%, respectively. There was no significant difference between the two groups (P <0.05). The effective rate was 92.68% in group C, which was better than group A and group B. Conclusion: Both flunarizine, divalproex and flunarizine combined with sodium valproate have a good preventive effect on the onset of migraine, and flunarizine combined with divalproex is more effective than migraine alone There is a better preventive effect, but it can cause more adverse reactions.