间质性肺纤维化是许多肺部疾病的最终结局 ,主要以肺组织细胞外基质的过度沉积为特征。在博莱霉素等致纤维化因素的作用下 ,肺组织产生的氧、氮等自由基使细胞膜发生脂质过氧化 ,损伤DNA和信号转导蛋白 ,使肺泡上皮遭到不可逆的破坏。同时肺细胞启动损伤修复机制 ,分泌转化生长 Interstitial pulmonary fibrosis is the culmination of many lung diseases and is characterized primarily by the excessive deposition of extracellular matrix of lung tissue. Under the action of bleomycin and other fibrogenic factors, the free radicals such as oxygen and nitrogen produced by the lung tissue cause the lipid peroxidation of the cell membrane and damage the DNA and the signal transduction protein, so that the alveolar epithelium is irreversibly damaged. At the same time lung cell damage repair mechanism, secretory growth and transformation