New small-molecule drug design strategies for fighting resistant influenza A

来源 :Acta Pharmaceutica Sinica B | 被引量 : 0次 | 上传用户:yanghong098
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
In fluenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination and small molecule anti-in fluenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-in fluenza small molecule drugs are more effective for the fi rst line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-in fluenza drugs currently available are admantane-based M2 protein blockers(amantadine and rimantadine) and neuraminidase(NA) inhibitors(oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of in fluenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-in fluenza drugs against resistant forms of in fluenza A virus. In this review,we fi rst give a brief introduction of the molecular mechanisms behind resistance, and then discuss new strategies in small-molecule drug development to overcome in fluenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs. Two major treatment strategies-vaccination and small molecule anti-in fluenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-in fluenza small molecule drugs are more effective for the fi rst line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-in fluenza drugs currently available are admantane-based M2 protein blockers (amantadine and rimantadine) and neuraminidase (NA) inhibitors (oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of in fluenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-in fluenza drugs against resistant forms of in fluenza A virus. In this review, we fi rst give a brief introduction of the molecular mechanisms behind r esistance, and then discuss new strategies in small-molecule drug development to overcome in fluenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs.
其他文献
劳动与技术课程的学习过程更多地表现为一种创造性实践过程,为学生提供激发创造潜力、发展创造能力的舞台,从而使学生的创造意识得到加强,能力得到发展。 The learning proc
目的以时间压缩策略为导向,探索社区卫生服务中心适用的自动发药系统,并评价该系统的实施效果。方法收集2012年8月1—23日三林社区卫生服务中心的处方信息,根据社区卫生服务
亲爱的奥星人:  告别了暑假,我们又迎来了开学的日子。也许你会对夏天有些意犹未尽,但是,秋天已经来了,我们又重新跟学校里的朋友们聚在了一起。谁长胖了?谁长高了?谁被晒黑了?小伙
一、概述:甜叶菊(Stevia rebaudana Bertoni)是菊科多年生草本植物。原产拉美热带高海拔地区。它的叶含甜分比蔗糖甜100-300倍的甜味物质—甜叶菊糖甙,含20-30的粗制品,提糖
【摘要】随着社会时代的快速发展,我国的教育事业的改革也随之不断的深入。英语的使用已经随着世界各国的密切联系变得越来越广泛,这就需要高校的英语教学也要跟上时代发展的步伐。本文通过对高校英语教学的模式进行分析,根据如今高校英语教学的现状提出相应的改良策略,以此来为学生提供相应的就业导向和帮助。  【关键词】就业导向 高校英语教学 改革  如今英语工作更多的是需要专业性较强的学生,扎实的英语知识作为最基
基于IODP建议书697-Full3号,IODP350航次的目的是通过对菲律宾海沉积物和基岩的钻探,获取长时间弧后岩浆成分的变化数据,进而了解伊豆-小笠原-马里亚纳(IBM)弧后体系的地壳形
上海国际电影节的影展单元是亚洲规模最大、也是最多元的电影展映活动。每年上海电影节都会集中展映数百部来自世界不同国家和地区的优秀影片。今年,观众将欣赏到自1993年电
尽管场地响应现象已是全球都公认的,然而对澳大利亚的许多地区,之前并没有研究过风化层属性对地震动的影响。为了描述风化层能改变地震动的特性,本文通过验证研究评估了为一
林业的技术政策取决于发展生产力的社会主义经济的要求。技术政策的主要内容是根据林业部门的长远发展所确定的近期任务和措施,以及根据生产、经济管理和科技各 Forestry’
自动极坐标实时差分监测系统在监测基准网的基础上,对监测数据进行实时差分处理,以消除和减弱各种误差对测量结果的影响,大幅度地提高了测量精度,为安全施工提供了准确、及时