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目的评价臭氧治疗外阴阴道假丝酵母菌病的有效性和安全性。方法采用随机对照、开放设计,入选外阴阴道假丝酵母菌病患者72例,其中试验组36例接受臭氧治疗,对照组36例接受达克宁栓治疗,于治疗前、治疗结束后第3天观察临床症状及体征,并进行阴道分泌物病原学检查。结果治疗结束后第3天,试验组和对照组的痊愈率分别为58.3%和61.1%,有效率分别为83.3%和88.9%,症状平均缓解时间分别为2.58d和2.36d,假丝酵母菌阴转率分别为94.4%和100%。2组之间比较差异均无统计学意义(P>0.05)。72例病例中无不良事件与严重不良事件发生。结论臭氧治疗外阴阴道假丝酵母菌病安全、有效。
Objective To evaluate the effectiveness and safety of ozone in the treatment of vulvovaginal candidiasis. Methods 72 patients with vulvovaginal candidiasis were selected as randomized and open design. Among them, 36 patients in experiment group received ozone treatment and 36 patients in control group received merketine treatment. Before treatment and 3 days after treatment, clinical observation Symptoms and signs, and vaginal discharge etiology. Results On the third day after the treatment, the cure rates of the experimental group and the control group were 58.3% and 61.1%, the effective rates were 83.3% and 88.9% respectively. The mean symptom relief time was 2.58 days and 2.36 days respectively. Candida albicans Negative conversion rates were 94.4% and 100% respectively. There was no significant difference between the two groups (P> 0.05). No adverse events and serious adverse events occurred in 72 cases. Conclusion Ozone treatment of vulvovaginal candidiasis is safe and effective.