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[Emanuel D等:J Immunol 1984 133(4):2202(英文)] 目前有两种方法制备人的单克隆抗体。一种是EB病毒(EBV)转化的外围血、淋巴结或脾细胞的免疫B细胞,产生长期传代的淋巴母细胞系。由这样的细胞系制备了很多种人的单克隆抗体。另一种是鼠×人和人×
[Emanuel D et al .: J Immunol 1984 133 (4): 2202 (English)] There are currently two ways to make human monoclonal antibodies. One is an immune B cell from peripheral blood, lymph node or spleen cells transformed with Epstein-Barr virus (EBV), producing long-passaged lymphoblastoid cell lines. Many kinds of human monoclonal antibodies have been prepared from such cell lines. The other is a mouse × people and people ×