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目的:观察痰瘀同治法改善咳嗽变异性哮喘(CVA)大鼠病症结合动物模型气道慢性炎症的疗效。方法:将72只大鼠分为正常对照组、模型对照组、激素吸入组、清肺化痰组、活血化瘀组、痰瘀同治组,制备咳嗽变异性哮喘痰瘀互结结合大鼠模型,灌胃给药15天,观察各组大鼠一般状态、中医证候、肺支气管病理组织形态、支气管肺泡灌洗液(BALF)嗜酸性粒细胞计数及测定血清Ig E水平的变化。结果:与正常对照组比较,模型组CVA大鼠支气管管腔狭窄,黏膜增厚,支气管壁及可见大量嗜酸性粒细胞浸润,BALF涂片EOS计数显著升高,血清中Ig E的含量显著升高,与正常对照组比较均有显著性差异(P<0.01)。激素治疗组及各中药治疗组,肺支气管病理、EOS计数及血清Ig E含量均有显著改善,与模型组比较有显著性差异(P<0.01),以激素治疗组及肝肺同治组指标改善最为显著。痰瘀同治法可以明显改善模型大鼠气滞血瘀、痰瘀互结的中医证候,改善大鼠一般状态。结论:痰瘀同治法可改善痰瘀互结的中医证候,降低CVA模型大鼠慢性气道炎症反应,调整免疫异常。
Objective: To observe the curative effect of phlegm and blood stasis to relieve airway chronic inflammation of cough variant asthma (CVA) rats combined with animal models. Methods: 72 rats were divided into normal control group, model control group, hormone inhalation group, Qingfei Huatan group, Huoxuehuayu group and phlegm and blood stasis Tongzhi group, and the rats with cough variant asthma The rats in each group were given gavage for 15 days. The general state, TCM syndrome, histopathology of lung bronchus, eosinophilic bronchoalveolar lavage fluid (BALF) count and serum IgE level were observed. Results: Compared with the normal control group, the bronchial stenosis, mucosal thickening, bronchial wall and a large number of eosinophilic infiltration in the bronchial wall were observed in model group CVA rats. The count of EOS in BALF smear was significantly increased and the content of Ig E in serum was significantly increased High, compared with the normal control group were significantly different (P <0.01). Hormone therapy group and Chinese medicine treatment group, pulmonary bronchial pathology, EOS count and serum Ig E levels were significantly improved, compared with the model group were significantly different (P <0.01) The most significant. Tongzhi method of phlegm and blood stasis can significantly improve TCM syndromes of qi stagnation, phlegm and blood stasis in rats, and improve the general state of rats. Conclusion: Phlegm and blood stasis can improve TCM syndromes of phlegm and blood stasis, reduce chronic airway inflammation and regulate immune abnormalities in CVA model rats.