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1 临床资料 1988-1995年,我院共收治肝硬变并上消化道出血经急诊内镜(出血距内镜检查24-48h之内或仍有活动性出血)检查确诊为食管静脉曲张破裂出血(esophageal variceal bleeding,EVB)者115例,其中以呕吐鲜血为首发症状者106例共121次列入本研究。男89例,女17例;平均年龄42(19-72)岁,有9例多次发生EVB,最高者达4次,均为男性患者。诊断EVE的标准为:①内镜下曲张静脉有出血表现;②未发现其它可能的出血病灶。判断EVB的发生时间以患者呕吐鲜血出现时计算,准确到小时。资料在计算机上用PEMS分析软件作x~2检查及圆形分布的统计学方法处理。 2 结果肝硬变EVB的发生以季节分为春(2-4月)、夏(5-7月)、秋(8-10月)、冬(11-1月)4组,分别占28.1%,14.1%,23.2%,34.7%,经x~2检验,冬季较夏季显著高发(P<0.01),春季发病也较夏季增多(P<0.05)。用圆形分布的统计方法检验,肝硬变EVB的昼夜发生有显著的周期性变化,每日有两个高峰,分
1 Clinical data 1988-1995, our hospital were treated cirrhosis and upper gastrointestinal bleeding by emergency endoscopy (bleeding from the endoscopy within 24-48h or still active bleeding) diagnosed as esophageal variceal bleeding (esophageal variceal bleeding, EVB) 115 cases, of which vomiting blood as the first symptom of 106 cases were included in the study of 121 cases. There were 89 males and 17 females with an average age of 42 (19-72) years old. There were 9 EVBs occurring in multiple occurrences, the highest being up to 4 times. All were male. EVE diagnostic criteria are: ① endoscopic varicose vein bleeding; ② found no other possible bleeding lesions. EVB to determine the time of occurrence of vomiting in patients with blood appears, accurate to the hour. Data on the computer using PEMS analysis software for x ~ 2 check and circular distribution of statistical methods. 2 Results The incidence of cirrhosis EVB was divided into four groups (April to April), summer (May to July), autumn (August to October) and winter (November to January), accounting for 28.1% , 14.1%, 23.2% and 34.7% respectively. The results of x2 test showed that the incidence of winter was significantly higher than that of summer (P <0.01), and the incidence of spring increased more than that of summer (P <0.05). With a circular distribution of statistical tests, liver cirrhosis EVB diurnal significant cyclical changes occur daily has two peaks, points