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目的观察经阴道超声引导下妊娠囊介入注射天花粉蛋白联合微波治疗异位妊娠的临床疗效。方法将140例符合异位妊娠未破裂型诊断的患者随机分为观察组和对照组各70例。观察组给予妊娠囊介入注射天花粉蛋白联合微波治疗,对照组给予妊娠囊介入注射天花粉蛋白治疗。比较2组临床疗效、治疗前后血β-人绒毛膜促性腺激素(β-h CG)水平和包块直径。结果观察组治疗总有效率为100.0%高于对照组的85.7%,差异有统计学意义(χ2=5.948,P<0.05)。2组治疗后血β-h CG水平逐渐下降,包块直径均逐渐减小,观察组在治疗后不同时间点的血β-h CG水平均显著低于对照组,包块直径均小于对照组,差异均有统计学意义(P<0.05)。结论经引道超声引导下妊娠囊介入注射天花粉蛋白联合微波治疗异位妊娠的成功率高,为临床治疗未破裂型异位妊娠提供了一种新的无创、易行的治疗方法。
Objective To observe the clinical efficacy of transvaginal ultrasound-guided gestational balloon injection of trichosanthin combined with microwave in the treatment of ectopic pregnancy. Methods A total of 140 patients with unruptured diagnosis of ectopic pregnancy were randomly divided into observation group (70 cases) and control group (70 cases). The observation group was treated with gestational sac injection of trichosanthin combined with microwave treatment, while the control group was treated with gestational sac injection of trichosanthin. The clinical efficacy of the two groups were compared. The level of β-hCG and the diameter of the mass before and after treatment were compared. Results The total effective rate in the observation group was 100.0% higher than that in the control group (85.7%), the difference was statistically significant (χ2 = 5.948, P <0.05). The levels of β-h CG in the two groups decreased gradually and the diameters of the lumps gradually decreased after treatment. The levels of β-h CG in the observation group were significantly lower than those in the control group at different time points after treatment , The differences were statistically significant (P <0.05). Conclusion The high success rate of injecting trichosanthin into the gestational sac under the guidance of the guidance channel ultrasound in the treatment of ectopic pregnancy is a new noninvasive and feasible treatment for unruptured ectopic pregnancy.