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目的:探讨血栓前状态分子标志物在高血压患者中的变化及意义;方法:选择新疆医科大学第一附属医院高血压科住院已确诊为高血压患者70例。用流式细胞术测定患者血小板表面CD41,CD62p;用放射免疫法检测血清ET-1;用ELISA方法检测血浆t-PA,PA全自动血凝分析仪检测凝血四项即血浆纤维蛋白原(FIB)水平、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT);结果:高血压组血小板表面CD62P的表达、血浆PAl-1、FIB三项指标均较正常组增高(P<0.05),而t-PA水平较正常组降低(P<0.05);高血压APTT、PT时间时间明显缩短(P<0.05);高血压组血小板表面CD41的表达,血清ET-1水平及TT时间与正常组比较无显著性差异(P>0.05);结论:检测血栓前状态分子标志在高血压患者中变化为临床早期发现、早期治疗血栓性疾病提供一种经济、方便、有效的实验室检查方法,指导临床采用合理的预防和治疗措施。
Objective: To investigate the changes and significance of prethrombotic state molecular markers in patients with hypertension. Methods: Seventy patients with hypertension were selected as the inpatients of hypertension department in the First Affiliated Hospital of Xinjiang Medical University. The platelet surface CD41 and CD62p were measured by flow cytometry, the serum ET-1 was detected by radioimmunoassay, the plasma t-PA and PA automatic hemagglutination analyzer were detected by ELISA. (APTT), prothrombin time (PT) and thrombin time (TT). Results: The expressions of CD62P, PA1-1 and FIB in plasma were higher in hypertension group than those in control group (P <0.05); the levels of t-PA in hypertension group were significantly lower than those in normal group (P <0.05); the levels of t-PA in hypertension group were significantly lower than those in normal group (P> 0.05). CONCLUSION: The changes of prethrombotic state molecular markers in patients with hypertension are early clinical discovery. Early treatment of thrombotic diseases provides an economical and convenient , Effective laboratory tests to guide clinical use of reasonable preventive and curative measures.