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目的:探究妊娠期高血压疾病患者血清胱抑素c(Scy-c)及尿β2微球蛋白(β2-MG)对早期肾损伤诊断的临床应用价值。方法:选择124例妊娠期高血压患者为研究对象,其中68例肾功能损伤患者为观察组1,56例肾功能正常患者为观察组2,并以48例健康体检孕妇为对照组,观察3组别血清Scy-c及尿β2-MG浓度,并研究血清Scy-c及尿β2-MG浓度与妊娠期高血压严重程度的关系。结果:观察组1、2及对照组Scy-c、尿β2-MG经方差分析差异均有统计学意义(P<0.05),SNK法两两比较各组间Scy-c、尿β2-MG差异也有统计学意义(P<0.05),在对照组、观察组2、观察组1 3组中血清Scy-c、尿β2-MG依次升高。结论:血清Scy-c、尿β2-MG对妊娠期高血压疾病患者早期肾功能受损有良好的监测作用。
Objective: To investigate the clinical value of serum cystatin c (Scy-c) and urinary β2-microglobulin (β2-MG) in the diagnosis of early renal damage in patients with hypertensive disorder during pregnancy. Methods: One hundred and twenty-four cases of hypertensive patients with gestational hypertension were selected as the study subjects. Among them, 68 cases of renal dysfunction were observed group, 1,56 cases of normal renal function were observed group 2 and 48 cases of healthy pregnant women as control group. Serum levels of Scy-c and urinary β2-MG were determined and the relationship between serum Scy-c and urinary β2-MG concentration and the severity of gestational hypertension was studied. Results: The difference of Scy-c and urinary β2-MG in observation group 1, 2 and control group was statistically significant (P <0.05). SNK method was used to compare the difference of Scy-c and urine β2-MG (P <0.05). Serum Scy-c and urinary β2-MG in control group, observation group 2 and observation group were significantly increased in turn. Conclusion: Serum Scy-c and urinary β2-MG have a good monitoring effect on early renal dysfunction in patients with hypertensive disorder complicating pregnancy.