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近来已认定丙型肝炎病毒(HCV)为大多数输血后或静脉内注射毒品成瘾后非甲非乙型肝炎(HNANB)的病因。然而HCV是否引起暴发性HNANB尚不明瞭。作者采用敏感而特异的聚合酶链反应(PCR)检测15例原因不明的暴发性肝衰竭患者的HCV RNA。结果表明,15例急性肝衰竭中无1例在血清或肝脏可测得抗-HCV或HCV RNA。相反,7例隐原性肝硬变患者中有5例在血清及/或肝脏中均可测得HCV RNA。无1例其他肝病患者和健康志愿者的血清或肝脏中可测得HCV RNA。复习15例急性肝衰竭患者中14例的肝组织学表现,未显示有单纯疱疹或巨细胞病毒感染的证据。作者认为,暴发性HNANB的临床表现与输血后肝炎不同,前者呈典型性地迅速
Hepatitis C virus (HCV) has recently been identified as the cause of most non-A, non-B hepatitis B (HNANB) following transfusion or intravenous drug addiction. However, whether or not HCV causes fulminant HNANB is unknown. The authors used a sensitive and specific polymerase chain reaction (PCR) to detect HCV RNA in 15 patients with unexplained fulminant hepatic failure. The results showed that none of the 15 acute liver failure cases detected anti-HCV or HCV RNA in serum or liver. In contrast, 5 of 7 patients with cryptogenic cirrhosis were able to detect HCV RNA in serum and / or liver. No HCV RNA was detected in the serum or liver of 1 other liver disease patients and healthy volunteers. Histological review of 14 patients in 15 patients with acute liver failure did not show evidence of herpes simplex or cytomegalovirus infection. The author believes that the clinical manifestations of fulminant HNANB and post-transfusion hepatitis is different, the former was typically rapid