长效避孕药复方炔雌醚每月口服一次,有很好的避孕效果,临床使用以来,受到广大服药妇女的欢迎。由于避孕药具有应用面广、服药时间长的特点,同时服药对象又都是正常健康妇女,因此,对药物安全性的要求就特别高。长效避孕片复方炔雌醚长期服用对妇女的健康有无影响的问题,也是药物的临床扩大试用所迫切需要解决的问题。为了提供有关药物安全性的资料,我们进行了复方炔雌醚的亚急性和慢性毒性试验。本文报道试验的主要结果。 Long-acting contraceptives compound ethinyl estradiol oral once a month, have a good contraceptive effect, since clinical use, the majority of women taking medicine are welcome. Because contraceptives are widely used, taking a long time characteristics, and taking the object are both normal and healthy women, therefore, the drug safety requirements are particularly high. Long-term contraceptives Compound ethynylestradiol long-term use of women’s health have no effect on the issue, but also the drug clinical trial to expand the urgent need to address the issue. To provide information on drug safety, we conducted subacute and chronic toxicity tests of the compound alkynephosphates. This article reports the main results of the experiment.